Youngest ever won the Italian 125cc champion, and third in the European championship (1995).* First rider in the history of the sport to win back-to-back premier class races for different manufacturers.
* The first rider in the 55-year history of Moto GP to take back-to-back victories riding machines from two different manufacturers, The 2003 Repsol Honda RC211V and the 2004 Gauloises Yamaha YZR M1.
* One of the two riders to win back-to-back titles on different machinery with Repsol Honda RC211V (2003) and with Gauloises Yamaha YZR M1 (2004).
* The youngest rider ever to have won World Championships in all three classes 125GP, 250GP, and the 500GP/Moto GP.* First in all time podium standings with 104 podiums in premier class.
* First in most podiums in a season with 16 podiums (2003 and 2005).
* First in fastest laps in a season with 12 fastest laps (2003).
* Only rider to win three races after starting the race from 11th or lower on the grid (British GP 2001, German GP 2006 & Dutch TT 2007).* First rider ever to win the MotoGP class at the age of 23.
* Second rider ever to win the premier class title with a two-stroke and a four-stroke machine.
* Fourth youngest rider ever to win the 500cc title.
* Eighth rider to have won three or more successive premier-class titles.
* Only rider to win seven consecutive races at his home Grand Prix at Mugello (2002-2008).
